Sometimes it can be evidenced that Windows 10 clients get random 'Access Denied' errors while accessing shares through connections that are accelerated through an Exinda appliance.
Windows 10 introduced a new version of SMB in the v3 family. While it is compatible back with previous versions of SMB technologies, the Exinda appliance still only works with SMB v2 protocols. This means that over the route, if acceleration is enabled, the Exinda will force the connection down, even if it is SMB v3 enabled, down to at least SMBv2 (or SMB v1 if the option is selected under Configuration > System > Optimization, on the "SMB" tab).
While Exinda is looking at the effects of Windows 10 and the changes made to the SMB protocols in the kernel, there might be a connection between getting random 'Access Denied' messages while accessing an SMB share on Windows Server 2008 or later, and going over an accelerated connection between Exindas. This situation does not happen for any other OS client except for Windows 10, and the behavior is intermittent.
If this problem occurs, please contact Exinda TAC for diagnostic gathering and further troubleshooting.